Reserpine and ajmaline
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چکیده
منابع مشابه
Reserpine and cerebral vasospasm.
Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance...
متن کاملBlockade of sodium and potassium channels in the node of Ranvier by ajmaline and N-propyl ajmaline.
The inhibition of sodium and potassium currents in frog myelinated fibres by ajmaline (AM) and its quaternary derivative, N-propyl ajmaline (NPA), depends on voltage-clamp pulses and the state of channel gating mechanisms. The permanently charged NPA and protonated AM interact only (or mainly) with open channels, while unprotonated AM affects preferently inactivated Na channels. Inhibition of N...
متن کاملStructural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry☆
Rauwolfia species (Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids (MIAs) such as reserpine, ajmalicine, ajmaline, serpentine and yohimbine. Reserpine, ajmalicine and ajmaline are powerful antihypertensive, tranquilizing agents used in hypertension. Yohimbine is an aphrodisiac used in dietary supplements. As there is no report on t...
متن کاملTreatment of hypertension with reserpine, with reserpine in combination with pentapyrrolidinium, and with reserpine in combination with Veratrum alkaloids.
The treatment of hypertension with reserpine is described. When used alone it produced adequate falls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its para-sympathetic sid...
متن کاملAjmaline in the management of cardiac arrhythmias.
A review of world literature on ajamline has been attempted; almost two third of the work is available in the German language. Ajmaline was isolated from rauwolfia serpentina, by Dr. Salimuzzaman Siddilui, and named after Hakim Ajmal Khan who who has used products of rauwolfia as antihypertentive and cardiac sedative. Antiarrhythmic effects of ajmaline are due to depression of atrioventricular ...
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ژورنال
عنوان ژورنال: Heart
سال: 1991
ISSN: 1355-6037
DOI: 10.1136/hrt.66.6.434